High
LET Molecular Radiation Biology
Works are
being carried out to study the response of
cancer and normal cell lines exposed to high LET
radiation.
-
Study
on genotoxic effect and mRNA expression of
human cord blood stem cells and blood
lymphocytes on exposure to high LET
radiation. Research on investigation of
mechanism of neoplastic transformation in
normal cells and radiation induced
leukemogenesis in hematopoietic stem cells
is also carried out.
-
Study
on activation of sensor proteins such as
ATM/ATR and kinases involved in DNA repair,
cell cycle arrest and apoptosis pathway in
lung cancer cells irradiated with high LET
radiation.
-
Evaluation
of factors responsible for Bystander effect
of high LET exposed cancer cells.
-
Assessment
of High and Low Let
radiation effects on Chinese
hamster ovary cells(CHO) or
Murine Macrophage cells with
exploration of cellular
mechanism involved. The
objective is to investigate
the time-dependent regulation
by Moringa
oleifera
leaf extract and its active
components (Quercetin,
Ferulic Acid, Rutin)
on the activity of the main
transcription factors (NF-κB
and nuclear transcription
factor erythroid 2p45-related
factor (Nrf2)) related to
antioxidant defense in
radiation induced oxidative
stress pathways.